In MySQL 5.0, it is possible to specify the size of the block buffers for an individual key cache using the key_cache_block_size variable. This permits tuning of the performance of I/O operations for index files.

The best performance for I/O operations is achieved when the size of read buffers is equal to the size of the native operating system I/O buffers. But setting the size of key nodes equal to the size of the I/O buffer does not always ensure the best overall performance. When reading the big leaf nodes, the server pulls in a lot of unnecessary data, effectively preventing reading other leaf nodes.

Currently, you cannot control the size of the index blocks in a table. This size is set by the server when the .MYI index file is created, depending on the size of the keys in the indexes present in the table definition. In most cases, it is set equal to the I/O buffer size.