If there are enough blocks in a key cache to hold blocks of an entire index, or at least the blocks corresponding to its non-leaf nodes, then it makes sense to preload the key cache with index blocks before starting to use it. Preloading allows you to put the table index blocks into a key cache buffer in the most efficient way: by reading the index blocks from disk sequentially.

Without preloading, the blocks are still placed into the key cache as needed by queries. Although the blocks will stay in the cache, because there are enough buffers for all of them, they are fetched from disk in a random order, not sequentially.

To preload an index into a cache, use the LOAD INDEX INTO CACHE statement. For example, the following statement preloads nodes (index blocks) of indexes of the tables t1 and t2:

mysql> LOAD INDEX INTO CACHE t1, t2 IGNORE LEAVES;
+---------+--------------+----------+----------+
| Table   | Op           | Msg_type | Msg_text |
+---------+--------------+----------+----------+
| test.t1 | preload_keys | status   | OK       |
| test.t2 | preload_keys | status   | OK       |
+---------+--------------+----------+----------+

The IGNORE LEAVES modifier causes only blocks for the non-leaf nodes of the index to be preloaded. Thus, the statement shown preloads all index blocks from t1, but only blocks for the non-leaf nodes from t2.

If an index has been assigned to a key cache using a CACHE INDEX statement, preloading places index blocks into that cache. Otherwise, the index is loaded into the default key cache.